Interstate highways serving Greater Holyoke include:
I‑91 – North to Northampton, Hatfield, Greenfield, and South to Springfield, Hartford.
I‑391 – South to Chicopee, and Springfield.
Immediately south of Holyoke is the Massachusetts Turnpike, accessible from exit 14 on I-91 South:
I‑90 – East to Worcester and Boston, and West to Stockbridge, and Albany
U.S. Highways serving Greater Holyoke include:
US 5 – Running from Ingleside to Smith's Ferry, connecting West Springfield to Easthampton and Northampton.
US 202 – Running from South Hadley via the Joseph E. Muller Bridge to Westfield, Massachusetts.
Massachusetts highways in the area include:
Route 116 – A minor freeway bypassing downtown Holyoke, connecting Chicopee to South Hadley via the Willimansett Bridge and the Vietnam Memorial Bridge.
Route 141 – A minor freeway connecting Easthampton over Mount Tom, through downtown via Appleton Street and Main Street in South Holyoke to Chicopee via I-391.
Bus and Rail
Several buses from the Pioneer Valley Transit Authority operate in the city including the Paper City Express with a route across town as well as routes to South Hadley, Westfield, Northampton, Amherst, and Springfield, connecting with Peter Pan Buslines at the Holyoke Transportation Center.
Passenger rail service returned to Holyoke in August 2015, after being absent since 1967. Amtrak's Vermonter stops at the Holyoke station once a day in each direction, and a New Haven–Springfield Shuttle pilot program will commence in Spring 2019 linking Holyoke to adjacent stations in Northampton and Springfield, as far north as Greenfield and south as New Haven, Connecticut, with two trains operating in the morning and the evening. The planned route will link provide service to commuters working in as far north as Greenfield and as far south as New Haven, Connecticut, with connections to New York City. The evaluation period of this pilot service will tentatively end in 2021 based on the results of the program.